Progress of Nucleophilic Substitution of Allylic Alcohols

Ruthenium catalysts for selective nucleophilic allylic substitution*

Recent developments in the chemistry of η3-allylruthenium(IV) complexes are due to their straightforward synthesis resulting from oxidative addition of allylic substrates to a ruthenium(II) center. Subsequent reaction with a nucleophile is the basis of their involvement in the catalytic allylic substitution reaction. We focus here on ruthenium-catalyzed substitution of allylic substrates by C-,...

Ruthenium-catalyzed regio- and enantioselective allylic substitution with water: direct synthesis of chiral allylic alcohols.

Enantioselective allylic substitution catalyzed by transitionmetal complexes is an important process in organic synthesis. For many years, mainly palladium complexes that contain chiral ligands have been employed as efficient catalysts in these reactions. Recent studies have demonstrated that chiral catalysts based on other transition metals show different regioselectivity in the synthesis of b...

Palladium-Catalyzed Nucleophilic Substitution of Alcohols: Mechanistic Studies and Synthetic Applications

Sawadjoon, S. 2013. Palladium-Catalyzed Nucleophilic Substitution of Alcohols. Mechanistic Studies and Synthetic Applications. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1092. 63 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8785-0. This thesis deals with the palladium-catalyzed nucleophilic substitution of π-activated alco...

Nucleophilic Substitution and Elimination

What does the term "nucleophilic substitution" imply? • A nucleophile is an the electron rich species that will react with an electron poor species • A substitution implies that one group replaces another. Nucleophilic substitution reactions occur when an electron rich species, the nucleophile, reacts at an electrophilic saturated C atom attached to an electronegative group (important), the lea...

Modern Nucleophilic Aromatic Substitution