Programmed cell death and the protozoan parasite
نویسندگان
چکیده
منابع مشابه
Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis.
Previous studies by the authors have shown that the protozoan parasite Blastocystis hominis succumbed to a cytotoxic monoclonal antibody with a number of cellular and biochemical features characteristic of apoptosis in higher eukaryotes. The present study reports that apoptosis-like features are also observed in growing cultures of axenic B. hominis upon exposure to metronidazole, a drug common...
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In this report, we have characterized two metacaspases of Leishmania donovani, L. donovani metacaspase-1 (LdMC1) and LdMC2. These two proteins show 98% homology with each other, and both contain a characteristic C-terminal proline-rich domain. Both genes are transcribed in promastigotes and axenic amastigotes of L. donovani; however, LdMC1 shows increased mRNA levels in axenic amastigotes. An a...
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In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads...
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C urrently there is much interest and excitement in the understanding of how cells undergo the process of apoptosis or programmed cell death. Understanding how, why, and when cells are instructed to die may provide insight into the aging process, autoimmune syndromes, degenerative diseases, and malignant transformation. This review focuses on the development of apoptosis and describes the proce...
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During programmed cell death (PCD) apoptosis is controlled by many factors such as proteases. With no specific protease (s) known during PCD in the developing nervous system so far, we sought to determine if any specific protease (s) is involved in this process and therefore used different protease inhibitors during PCD (from embryonic day 6 to 10) in chick embryos. Among the inhibitors commerc...
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ژورنال
عنوان ژورنال: Parasitology
سال: 2006
ISSN: 0031-1820,1469-8161
DOI: 10.1017/s0031182006000801