Prognostic value of liver stiffness in patients with tricuspid regurgitation

Abstract Background It has been known that liver stiffness (LS) assessed by transient elastography is associated with right heart dysfunction and the severity of tricuspid regurgitation. However, predictive value LS for adverse outcome in patients regurgitation (TR) uncertain. Objectives The aim this study was to identify prognostic moderate or greater degree TR. Methods A total 257 severe TR who underwent both echocardiography were retrospectively analysed. Patients have congenital disease chronic including, viral hepatitis, alcoholic disease, autoimmune hepatocellular carcinoma excluded. Severe defined as elevated kilopascal (kPa) ≥11 (High kPa). Primary composite all-cause death unplanned admission failure. Results One hundred forty-one had 116 twenty-eight (50%) stiffness. During a follow-up period (median 637 days, IQR 1317), (45.1%) primary outcomes occurred. In Kaplan-Meier analysis, high kPa showed worst outcome. Moreover, worse clinical group than low kPa. multivariate Cox regression independently (HR=1.66, 95% CI: 1.28–2.16), p<0.001). Conclusions fibrosis measured may be useful marker cardiac hepatopathy related TR, contribute predict prognosis Funding Acknowledgement Type funding sources: None.