Prognostic potential of ERG (ETS-related gene) expression in prostatic adenocarcinoma
نویسندگان
چکیده
منابع مشابه
Comparison of Matrix Metalloproteinases 2 mRNA Expression in Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia
Background and Aims: Prostate cancer is the second most common cancer in men worldwide in men. Matrix metalloproteinase 2 (MMP2) has a role in the invasion and destruction of the basement membrane and the extra-cellular matrix and facilitating the process of tumor cell invasion. The present study was conducted to compare the expression of MMP2 gene in prostate cancer (PCa) and benign prostatic ...
متن کاملThe erg gene: a human gene related to the ets oncogene.
We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4.6 kilobases long) revealed that this gene encodes a 363-residue protein whose predicted amino acid sequence showed a homology of approximately equal to 40% and approximately equal to 70% to two domains corresponding to the 5...
متن کاملERG upregulation and related ETS transcription factors in prostate cancer.
The aim of this study was to identify and validate differentially expressed genes in matched pairs of benign and malignant prostate tissue. Samples included 29 histologically verified primary tumors and 23 benign controls. Microarray analysis was initially performed using a sequence verified set of 40,000 human cDNA clones. Among the genes most consistently and highly upregulated in prostate ca...
متن کاملExpression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients
AIM Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show ...
متن کاملcomparison of matrix metalloproteinases 2 mrna expression in prostatic adenocarcinoma and benign prostatic hyperplasia
background and aims: prostate cancer is the second most common cancer in men worldwide in men. matrix metalloproteinase 2 (mmp2) has a role in the invasion and destruction of the basement membrane and the extra-cellular matrix and facilitating the process of tumor cell invasion. the present study was conducted to compare the expression of mmp2 gene in prostate cancer (pca) and benign prostatic ...
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ژورنال
عنوان ژورنال: International Urology and Nephrology
سال: 2013
ISSN: 0301-1623,1573-2584
DOI: 10.1007/s11255-013-0406-2