Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia
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منابع مشابه
Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia.
Prognosis of B-cell chronic lymphocytic leukemia (CLL) is based on clinical staging whose limitation is the failure to assess whether the disease will progress or remain stable in early stage (Binet A, or Rai 0, I, II) patients. We previously reported that soluble CD23 (sCD23), a protein derived from the B-cell membrane CD23 Ag, is selectively elevated in the serum of CLL patients. This prospec...
متن کاملPrognostic impact of the serum levels of soluble CD23 in B-cell chronic lymphocytic leukemia.
E, Biondi F, Lo Coco F, Grignani F, Pelicci PG: Acute promyelocytic REFERENCES leukemia: From genetics to treatment. Blood 83:10, 1994 1. Wada H, Mizutani S, Nishimura J, Usuki Y, Kohsaki M, Komai 5. Nucifora G, Rowley JD: The AML1 and ETO genes in acute M, Kaneko H, Sakamoto S, Delia D, Kanamaru A, Kakishita E: myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353, 1994 Establishment and molec...
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-CLL is frequently accompanied by decreased levels of serum immunoglobulins which increases patients susceptibility to infections (1,2). Low levels of IgA, IgM and IgG occur in 30%, 30% and 10% of B-CLL patients respectively at the time of diagnosis. The appearance of decreased levels of immunoglobulins is a continuos process developing spontaneously during the untreated course of the disease. ...
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Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expre...
متن کاملPrognostic factors in chronic lymphocytic leukemia.
The Rai staging system is widely used and is easy to apply in clinical practice. The system introduced by Binet et al offers an advantage that it consists only of three stages and, therefore, is more practical for initiation of controlled therapeutic trials than the five-stage Rai system. However, when we take into consideration the survival curves, it is important to note that the Rai system h...
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ژورنال
عنوان ژورنال: Blood
سال: 1996
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v88.11.4259.4259