Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer

The DNA damage response (DDR) is critical for maintaining genome stability, and abnormal DDR—resulting from mutations in damage-sensing repair proteins—is a hallmark of cancer. Here, we aimed to investigate the predictive power DDR gene tumor mutational load (TML) survival outcomes cohort 22 rectal cancer patients who received pre-operative neoadjuvant therapy. Univariate analysis revealed that TML-high TP53 were significantly associated with worse overall (OS) retaining significance multivariate analyses. Kaplan–Meier analyses further showed was disease-free (p = 0.036) OS 0.024) results our patient cohort. A total 53 somatic identified samples eight (36%) containing genes, including ATM, ATR, CHEK2, MRE11A, RAD50, NBN, ERCC2 TP53. most frequently mutated gene, 0.023) Thus, data indicate TML have prognostic value may be important independent biomarkers management. This suggests determination receiving therapy should include consideration initial genetic status.