Progesterone levels on the human chorionic gonadotropin trigger day affect the pregnancy rates for embryos transferred at different stages of development in both general and selected IVF/ICSI populations

Abstract Background Two meta-analyses have shown that pregnancy and birth rates are significantly higher after blastocyst transfer than cleaved embryo transfer. Other studies revealed a serum progesterone level > 1.5 ng/ml on the trigger day is responsible for premature luteinization associated with low rate. The objectives of this retrospective study were to determine whether gave at 3 in both general selected IVF/ICSI populations, influenced Method We studied cycles GnRH antagonist - FSH/hMG protocols population ( n = 1210) “top cycle” 677), 5 or 3. couples had meet following criteria: female age < 35, first second cycle, one two embryos transferred. recorded predictive factors calculated oocyte index (POI), progesterone:estradiol ratio (P:E2 ratio), follicle (> 14 mm) (PFI). Results In population, clinical rate was (33.3%) (25.3%; p 0.01); same true (32.1 22.8%, respectively, 0.01). differences between groups not significant (respectively 35.7% vs. 35.8% rate, 33.9 34.9% rate). levels eve itself lower pregnant women found threshold 0.9 ng/ml, as also reported by other researchers. POI PFI appear value transfers. Conclusions Blastocyst transfers but population. predicted likelihood pregnancy.