منابع مشابه
Genome-wide profiling of DNA methylation in human cancer cells.
Global changes in DNA methylation correlate with altered gene expression and genomic instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) method that can assess DNA methylation on a genomic scale. MSDS is a simple, low-cost method that combines the use of methylation-sensitive restriction enzymes with second generation sequencing technology. DNA methylation ...
متن کاملGenome-Wide Methylation Profiling of Schizophrenia
Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution. We have performed 26 high-resolution ge...
متن کاملPredicting Genome-wide DNA Methylation in Humans
Predicting Genome-wide DNA Methylation in Humans
متن کاملGenome-wide analysis of DNA methylation patterns.
Cytosine methylation is the most common covalent modification of DNA in eukaryotes. DNA methylation has an important role in many aspects of biology, including development and disease. Methylation can be detected using bisulfite conversion, methylation-sensitive restriction enzymes, methyl-binding proteins and anti-methylcytosine antibodies. Combining these techniques with DNA microarrays and h...
متن کاملGenome-wide DNA methylation profile in mungbean
DNA methylation on cytosine residues is known to affect gene expression and is potentially responsible for the phenotypic variations among different crop cultivars. Here, we present the whole-genome DNA methylation profiles and assess the potential effects of single nucleotide polymorphisms (SNPs) for two mungbean cultivars, Sunhwanogdu (VC1973A) and Kyunggijaerae#5 (V2984). By measuring the DN...
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ژورنال
عنوان ژورنال: Epigenetics & Chromatin
سال: 2016
ISSN: 1756-8935
DOI: 10.1186/s13072-016-0075-3