Profile Tumor Necrosis Factor Alpha and Procalcitonin in Preeclampsia and Preeclampsia with Sepsis

BACKGROUND: Preeclampsia is hypertension in pregnancy which are characterized by high blood pressure, proteinuria that occur after 20 weeks of GA. remains a massive cause maternal morbidity and mortality 50.000 death annually. The preeclampsia still unclear but there possibility caused immunological processes micro placenta environment during the early age pregnancy. It suggested cytokines such as tumor necrosis factor (TNF-α) has an important role pathogenesis preeclampsia. extreme feature systemic inflammatory response Systemic inflammation can organ damage induce sepsis. pathophysiology initiated level pro-inflammatory cytokine released peripheral mononuclear cell (PBMC). Beside cytokine, marker sepsis be shown procalcitonin (PCT) produced PBMC activated TNF-α. AIM: objective study to evaluate profile plasma levels TNF-α PCT analyze their correlation normotensive pregnant woman, preeclamptic with METHODS: An observational cross-sectional study. sample were normotensive, preeclamptic, (n = 18) Bangil Hospital, Pasuruan. was measured ELISA. statistical analysis SPSS 18.0 p < 0.05. RESULTS: This showed significantly higher than control (p 0.05) not significant difference > 0.05). compared no between patients CONCLUSION: statistically different group, There group. woman levels.