Professor Aristides Leão. Much More Than Spreading Depression

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Professor Aristides Leão. Much more than spreading depression.

Professor Leão described cortical spreading depression (CSD) in 1944 and changed the way migraine pathophysiology is scientifically conceived. This Brazilian professor and researcher developed his career in Rio de Janeiro. Because of him, the city once became the CSD world capital, attracting scientists from many laboratories around the globe. Aristides Leão was first and foremost a naturalist,...

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Aristides Leão: a birth centennial homage with comments on his spreading depression.

The year of 2014 is the birth centenary of Aristides Azevedo Pacheco Leão (1914-1993), and also marks seventy years of the publication of his discovery of the novel electrophysiological phenomenon, named by him "spreading depression" (SD), soon designated "Leão's wave" or "Leão's spreading depression". This was a remarkable scientific milestone, and the author must be celebrated for this achiev...

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This essay looks at the historical significance of three APS classic papers that are freely available online: Leão AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390, 1944 (http://jn.physiology.org/cgi/reprint/7/6/359). Leão AAP. Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 391–396, 1944 (http://jn.physiolog...

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ژورنال

عنوان ژورنال: Headache: The Journal of Head and Face Pain

سال: 2009

ISSN: 0017-8748,1526-4610

DOI: 10.1111/j.1526-4610.2008.01210.x