PRODUCTION OF TL ANTIBODY BY MICE IMMUNIZED WITH TL- CELL POPULATIONS

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Production of Tl Antibody by Mice Immunized with Tl- Cell Populations

TL(-) mice make TL antibody when immunized with spleen or bone marrow cells from TL(+) donors, despite the fact that these cells do not express TL antigen. This has been shown to depend on maturation of TL(-) precursors, contained in the inoculum, into TL(+) cells under influence of the recipient's thymus; the differentiated TL(+) cells then evoke production of TL antibody.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1973

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.137.2.533