Production of Ergot Alkaloids by the Japanese Isolate <i>Claviceps purpurea</i> var. <i>agropyri</i> on Rice Medium

Ergot alkaloids (EAs) are secondary metabolites produced by ergot fungi (e.g., Claviceps purpurea), which parasites of Gramineae grasses. EAs and their analogs used to treat migraine, postpartum uterine bleeding, Parkinson's syndrome. Recent studies have reported additional new bioactive activities analogs, making them essential compounds for drug development, repositioning, clinical applications. industrially field cultivation or liquid fermentation in the mycelial phase, but there few published production cereal culture thus this approach is poorly understood. This study searched strains that produce cultured artificially then selected were on media (white rice, brown rye) examine ability each medium. C. purpurea var. agropyri Clavine-type pyroclavine (1), festuclavine (2), agroclavine (3) phase. When with white rye, 1 - 3 all media. The total amount medium (150 g per Roux flask) was 2220.5 ± 564.1 ?g 920.0 463.6 595.4 52.1 rye. rice supported highest 3, being about 34 times higher than T25 (190 mL L Erlenmeyer (equivalent flask).