Production of Antibacterial Compounds from Aspergillus terreus Against MDR Acinetobacter baumannii Using Co-culture

Acinetobacter baumannii is a bacterial pathogen, associated with hospital and community acquired infections. It one of the most common, opportunistic, serious multidrug resistant bacteria (MDR). considered global problem. The use natural compounds such as fungal metabolites an alternative to antibiotics being explored overcome issue antimicrobial resistance. Among fifty spp. isolated from different sources, only Aspergillus terreus showed antibacterial effect against A. baumannii. Co-culture applied produce bioactive in higher amounts and/or induce production new secondary metabolites. Several solvents chromatographic techniques were used isolate, fractionate, purify terreus/ co-culture Ethyl acetate extract was potent MDR baumannii, comparison chloroform methanol extracts. Characterization structure elucidation purified compound ethyl performed using LC-MS, 1H NMR, IR. identified terreusinone A minimum inhibitory concentration 160 µg.µl-1against This first record determine particularly