Production and characterization of low molecular weight heparin obtained by modified double emulsion method with solvent evaporation
نویسندگان
چکیده
منابع مشابه
Preparation, properties and preclinical pharmacokinetics of low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle
Low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (LMWH-ISL-SLN) was developed for injective application. The morphological observation, particle diameter and zeta potential of LMWH-ISL-SLN were characterized using transmission electron microscopy (TEM) and a Malvern Zetasizer. Its entrapment efficiency (EE) and drug loading (DL) were determined by ultracen...
متن کاملPhysicochemical Characterization of a Hydrophilic Model Drug-Loaded PHBV Microparticles Obtained by the Double Emulsion/Solvent Evaporation Technique
Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsulação (EE). O resultado mais elevado de EE (9,76%) fo...
متن کاملPreparation, properties and preclinical pharmacokinetics of low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle
Low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (LMWH-ISL-SLN) was developed for injective application. The morphological observation, particle diameter and zeta potential of LMWH-ISL-SLN were characterized using transmission electron microscopy (TEM) and a Malvern Zetasizer. Its entrapment efficiency (EE) and drug loading (DL) were determined by ultracen...
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In this work, we are motivated by the need to produce particles of well-controlled size, shape and morphology for general application in catalysis, environmental remediation, nanomedicine, pharmaceuticals, the development of new materials, and other fields. Moreover, our approaches are guided by the desire for continuous and scalable production, in contrast to the batch-wise processes typically...
متن کاملPreparation of Eudragit E100 microspheres by modified solvent evaporation method.
The objective of this investigation was to develop the hollow microspheres as a new dosage form of floating drug delivery system with prolonged stomach retention time. Hollow microspheres containing ranitidine hydrochloride were prepared by solvent evaporation method using Eudragit RLPO dissolved in a mixture of dichloromethane and ethanol. The maximum yield and drug loading amount of hollow mi...
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ژورنال
عنوان ژورنال: Pharmacy & Pharmacology International Journal
سال: 2019
ISSN: 2379-6367
DOI: 10.15406/ppij.2019.07.00263