Process analysis of fluidized bed granulation
نویسندگان
چکیده
منابع مشابه
Granulation Time in Fluidized Bed Granulators
Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...
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Ž . In this study, the rapid expansion of supercritical fluid solution RESS process was employed for the coating granulation of fine particles in a fluidized bed and its mechanism was examined. The rapid expansion of the supercritical solution causes very high supersaturating ratio of solute in the spraying flow, forming a large number of superfine nuclei. The superfine nuclei deposited on the ...
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Fluidized bed spray granulation is a process to obtain coarse-grained particles directly from suspensions, solutions or melts, ready for sale without any need for post-treatment. The process combines spray drying with granulation and classification, thus allowing the product particle size distribution to be adjusted according to customer demands. Well-known applications include pharmaceutical p...
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Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the excipient and was granulated with several binders, including hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone. The viscosity, density, and surface tension of the binder solution, contact angle, and the work done ...
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A model was developed taking into consideration the heat and mass transfer processes in liquidsprayed fluidized beds. Such fluidized beds (FB) are used for granulation, coating and agglomeration. Conclusions are drawn on the relevance of particle dispersion, spraying and drying to temperature and concentrations distributions. In extension, the model was coupled with a population balance model t...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2001
ISSN: 1530-9932
DOI: 10.1208/pt020421