PROBLEMS IN POSTOPERATIVE ADMINISTRATION OF ANTACIDS

Antipeptic activity of antacids.

An in vitro experiment based on the digestion of haemoglobin with pepsin was carried out to test the claim made by some manufacturers that the antacids used in their proprietary preparations had an intrinsic antipeptic activity independent of the change brought about by alteration of pH. In no case could these claims be substantiated.

Parietal cell hyperplasia induced by long-term administration of antacids to rats.

Suspension of magnesium and aluminum hydroxide (30--60 mEq/24h) or a comparable volme of water was orally administered by gastric intubation to two groups of 20 male Wistar rats each over 60 days. The antacid treatment led to a significant increase in the height (0.464 +/- 0.02 mm v. 0.318 +/- 0.06) and in the volume (472 +/- 32 mm3v.328 +/- 45) of the fundic mucosa of the stomach, in the avera...

Comparative study of commercial antacids

Comparative study of four antacids.

Four antacid preparations have been studied in a stratified, randomized, double-blind trial to evaluate criteria which determine patients' acceptance of this type of therapy. There was a considerable range of judgements about palatability, but preference was determined not only by factors such as the smell, taste, texture and after-taste of the preparation, but also by the order in which the an...

In Vitro Evaluation of Some Ayurvedic Antacids

The ayurvedic proprietary antacid preparations available in the Indian market were analysed for their antacid activity and compared with allopathic antacid preparations. This study urges the need for standardization of antacid products with in vitro  parameters.