Probing protein flexibility reveals a mechanism for selective promiscuity
نویسندگان
چکیده
منابع مشابه
Probing protein flexibility reveals a mechanism for selective promiscuity
Many eukaryotic regulatory proteins adopt distinct bound and unbound conformations, and use this structural flexibility to bind specifically to multiple partners. However, we lack an understanding of how an interface can select some ligands, but not others. Here, we present a molecular dynamics approach to identify and quantitatively evaluate the interactions responsible for this selective prom...
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ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.22889