Probable Causes of Alzheimer’s Disease

A three-part mechanism is proposed for the induction of Alzheimer’s disease: (1) decreased blood lactic acid; (2) increased ceramide and adipokines; (3) folic acid. The age-related nature these mechanisms comes from age-associated muscle mass, visceral fat changes in diet. This also explains why many people do not develop disease. Simple lifestyle diet can prevent disease caused by a cascade events that culminates damage to blood–brain barrier neurons. keeps toxic molecules out brain retains essential brain. Lactic acid nutrient produced exercise. Damage endothelial cells pericytes inadequate leads damage. Inadequate folate intake oxidative stress induced activation transient receptor potential cation channels nitric oxide synthase barrier. NAD depletion due nicotinamide alterations kynurenine pathway damages Changes microRNA levels may be terminal cause neuronal death leading new presented involving acid, ceramide, IL-1β, tumor necrosis factor α, folate, nicotinamide, metabolites microRNA.