منابع مشابه
Efficient Exact Maximum a Posteriori Computation for Bayesian SNP Genotyping in Polyploids
The problem of genotyping polyploids is extremely important for the creation of genetic maps and assembly of complex plant genomes. Despite its significance, polyploid genotyping still remains largely unsolved and suffers from a lack of statistical formality. In this paper a graphical bayesian model for SNP genotyping data is introduced. This model can infer genotypes even when the ploidy of th...
متن کاملSNP genotyping and parameter estimation in polyploids using low-coverage sequencing data
Motivation Genotyping and parameter estimation using high throughput sequencing data are everyday tasks for population geneticists, but methods developed for diploids are typically not applicable to polyploid taxa. This is due to their duplicated chromosomes, as well as the complex patterns of allelic exchange that often accompany whole genome duplication (WGD) events. For WGDs within a single ...
متن کاملLocation Reparameterization and Default Priors for Statistical Analysis
This paper develops default priors for Bayesian analysis that reproduce familiar frequentist and Bayesian analyses for models that are exponential or location. For the vector parameter case there is an information adjustment that avoids the Bayesian marginalization paradoxes and properly targets the prior on the parameter of interest thus adjusting for any complicating nonlinearity the details ...
متن کاملPolyploids require Bik1 for kinetochore–microtubule attachment
The attachment of kinetochores to spindle microtubules (MTs) is essential for maintaining constant ploidy in eukaryotic cells. Here, biochemical and imaging data is presented demonstrating that the budding yeast CLIP-170 orthologue Bik1is a component of the kinetochore-MT binding interface. Strikingly, Bik1 is not required for viability in haploid cells, but becomes essential in polyploids. The...
متن کاملEVOLUTION OF POLYPLOIDS Reference: Harlan and deWet (1975) Origins of Polyploids Literatures relating to evolution of polyploids
Class I: Chromosome increase occurs in the first generation through the union of gametes one or both of which are unreduced. Can occur following selfor crosspollination. Class II: Chromosome doubling occurs in offspring of a hybrid with meiotic disturbances leading to unreduced gametes. It’s a second generation phenomenon: F2, BC1 or F1 crossed to a third parent. Class III: Chromosomal doubling...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2019
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btz852