Prions and Related Phenomena

Steep. Short-Crested Waves and Related Phenomena

Steep, short-crested waves, as well as a large variety of three-dimensional propagating wave patterns have been created in laboratory, utilizing a plunging half-cone. Monochromatic waves, over a range of frequencies and amplitudes through breaking and including soliton wave groups near resonance, have been observed and studied in a small wave flume. This monochromatic wavemaker creates complex ...

Shock and Related Capillary Phenomena

Prions.

The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...

PrionHome: A Database of Prions and Other Sequences Relevant to Prion Phenomena

Prions are units of propagation of an altered state of a protein or proteins; prions can propagate from organism to organism, through cooption of other protein copies. Prions contain no necessary nucleic acids, and are important both as both pathogenic agents, and as a potential force in epigenetic phenomena. The original prions were derived from a misfolded form of the mammalian Prion Protein ...

Prions.

Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...