Prion-Dependent Lethality ofsup45Mutants inSaccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Prion protein gene polymorphisms in Saccharomyces cerevisiae.
The yeast Saccharomyces cerevisiae genome encodes several proteins that, in laboratory strains, can take up a stable, transmissible prion form. In each case, this requires the Asn/Gln-rich prion-forming domain (PrD) of the protein to be intact. In order to further understand the evolutionary significance of this unusual property, we have examined four different prion genes and their correspondi...
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protein familycausehypersensitivity toacetic acid inSaccharomyces cerevisiae aswell as inYarrowia lipolytica Marcus Gentsch, Margret Kuschel, Susan Schlegel & Gerold Barth Department of Pediatrics, University Clinic Carl Gustav Carus, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, University Clinic Carl Gustav Carus, Dresden, Germany; Institute of Biochemistry and Molecula...
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Vps30p/Apg6p is required for both autophagy and sorting of carboxypeptidase Y (CPY). Although Vps30p is known to interact with Apg14p, its precise role remains unclear. We found that two proteins copurify with Vps30p. They were identified by mass spectrometry to be Vps38p and Vps34p, a phosphatidylinositol (PtdIns) 3-kinase. Vps34p, Vps38p, Apg14p, and Vps15p, an activator of Vps34p, were coimm...
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Objective(s): To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. Materials and Methods: Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes ...
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The budding yeast Saccharomyces cerevisiae is a valuable model system for studying prion-prion interactions as it contains multiple prion proteins. A recent study from our laboratory showed that the existence of Swi1 prion ([SWI(+)]) and overproduction of Swi1 can have strong impacts on the formation of 2 other extensively studied yeast prions, [PSI(+)] and [PIN(+)] ([RNQ(+)]) (Genetics, Vol. 1...
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ژورنال
عنوان ژورنال: Prion
سال: 2007
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.1.2.4533