Prion degradation pathways: Potential for therapeutic intervention
نویسندگان
چکیده
منابع مشابه
Prion degradation pathways: Potential for therapeutic intervention
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating the degradation of PrP(Sc) have shown efficacy in experimental models of prion disease. Here, we de...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2015
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2014.12.009