Principles of gene regulation across tissues
نویسندگان
چکیده
منابع مشابه
Extensive post-transcriptional regulation across human tissues
Transcriptional and post-transcriptional regulation shape tissue-type-specific proteomes, but their relative contributions remain contested. Estimates of the factors determining protein levels in human tissues do not distinguish between (i) the factors determining the variability between the abundances of different proteins and (ii) the factors determining the physiological variability of the s...
متن کاملGenome-wide analysis of enhancer RNA in gene regulation across 12 mouse tissues
Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a computational analysis on eRNAs using genome-wide data across 12 mouse tissues. The expression of genes targeted by transcribing enhancer is positively correlated with eRNA expression and significantly higher than expressio...
متن کاملEvolutionary-conserved gene expression response profiles across mammalian tissues.
Gene expression responses are complex and frequently involve the actions of many genes to effect coordinated patterns. We hypothesized these coordinated responses are evolutionarily conserved and used a comparison of human and mouse gene expression profiles to identify the most prominent conserved features across a set of normal mammalian tissues. Based on data from multiple studies across mult...
متن کاملDissecting Cis Regulation of Gene Expression in Human Metabolic Tissues
Complex diseases such as obesity and type II diabetes can result from a failure in multiple organ systems including the central nervous system and tissues involved in partitioning and disposal of nutrients. Studying the genetics of gene expression in tissues that are involved in the development of these diseases can provide insights into how these tissues interact within the context of disease....
متن کاملEukaryotic Gene Regulation | Principles of Biology from Nature Education
The nucleosome. Digital model of a nucleosome, the fundamental structural unit of chromosomes in the eukaryotic cell nucleus, derived from X-ray crystallography data. Each nucleosome consists of a core group of histone proteins (orange) wrapped in chromosomal DNA (green). The nucleosome is a structure responsible for regulating genes and condensing DNA strands to fit into the cell's nucleus. Re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2017
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2017.94