Primary antibody deficiencies in the context of normal B-cell differentiation
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چکیده
منابع مشابه
Primary antibody deficiencies in the context of normal B-cell differentiation
Primary antibody deficiencies (PAD) form the largest group of inherited disorders of the immune system. They are characterized by a marked reduction or absence of serum immunglobulins (Ig) and/or a poor response to vaccination due to disturbed B-cell differentiation. PAD can be divided in agammaglobulinemia, Ig class switch recombination defects (formerly called hyper IgM syndromes), and idiopa...
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Primary B-Cell Deficiencies Reveal a Link between Human IL-17-Producing CD4 T-Cell Homeostasis and B-Cell Differentiation
IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation and the circulating follicular T helper subset was recently shown to be enriched in Th17 cells able to help B-cell differentiation. We investigated a putative link between Th17-cell homeostasis a...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2010
ISSN: 1479-5876
DOI: 10.1186/1479-5876-8-s1-i11