Previous Hospitalization a Risk Factor for Drug-Resistant TB

Multidrug resistant TB and extensively drug resistant TB

Resistance to anti-TB drugs is not an emerging phenomenon, but a process closely related to the implementation of chemotherapy against TB. Clinical evidence to prove the development of resistance to anti-TB drugs was provided by the Medical Research Council team in 1948, shortly after using streptomycin in (as?) monotherapy for TB treatments 1. As isoniazid, PAS and streptomycin were first used...

Management of Drug-Resistant TB

Cirrhosis as a risk factor to drug-resistant tuberculosis.

ARÉVALO et al. [1] are correct to be cautious in accepting as true the unexpected and apparently biologically implausible association between hepatic cirrhosis and drug-resistant tuberculosis (TB) found in their study. However, the explanations they offered for this finding are not satisfactory and merit further consideration. If the diagnosis of cirrhosis was not made in some patients, which i...

[Hospitalization for bronchiolitis: a risk factor for recurrent wheezing].

This longitudinal study evaluated the role of hospitalization for acute bronchiolitis as a risk factor for recurrent wheezing. Participants were children from a 1993 cohort in a southern Brazilian city. Hierarchical multivariate analysis showed that previous hospitalization for bronchiolitis was the most important risk factor for recurrent wheezing, with an odds ratio of 4.9. This strong associ...

Extensively drug resistant tuberculosis (XDR-TB): A potential threat

Emergence of extensively drug resistant tuberculosis (XDR-TB) has been reported by more than 55 countries. XDR-TB is considered as untreatable and highly fatal disease. In developing countries like India, number of cases of multi-drug resistant tuberculosis (MDR-TB) and XDR-TB are increasing. Emergence of resistance to Isoniazid and Rifampicin, the two most effective and well tolerated agents, ...