Preventive strategies in endothelin-induced renal failure
نویسندگان
چکیده
منابع مشابه
Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats
Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF). ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...
متن کاملPotential contribution of endothelin to renal abnormalities in glycerol-induced acute renal failure in rats.
We studied the possible participation of endothelin-1 (ET-1) in the pathogenesis of renal damage in glycerol-induced acute renal failure (ARF). Cortical mRNA expression of ET-1 increased, peaking at 10 hr postinjury, but this did not occur in the medulla, plasma concentration and urinary excretion of ET-1 also increased in this model. There was no change in ETA receptor mRNA, whereas the ETB re...
متن کاملeffect of endothelin-a receptor blockade on the early phase of ischemia/reperfusion-induced acute renal failure in anesthetized rats
background: previous studies have shown increases in endothelin (et) concentration of plasma and renal tissues in acute renal failure (arf). et has a potent vasoconstrictor effect, through binding with its et a receptors, and may play some roles in renal hemodynamic dysfunction in arf. objective: to examine the beneficial effect of a selective et a -receptor antagonist on renal dysfunction and...
متن کاملExpression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice.
Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors (ET(A)R and ET(B)R) are variably expressed. Although renal functional and structural changes are similar between ischemic and nephrotoxic ARF, there are few reports on the alteration in the ET system in nephrotoxic ARF. This study was, therefore, undertaken to investigate ch...
متن کاملPlasma endothelin levels in hypertension and chronic renal failure.
Endothelin-1 is a novel endothelium-derived vasoconstrictive peptide. Using a highly specific and sensitive radioimmunoassay for endothelin-1, plasma levels of immunoreactive endothelin-1 were measured in 32 research subjects with normal renal function (21 normal subjects and 11 patients with essential hypertension), 24 patients with nondialyzed chronic renal failure, and 51 patients undergoing...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.06747.x