Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid
نویسندگان
چکیده
منابع مشابه
Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by -Lipoic Acid
The aim of the present study was to investigate whether a dietary supplementation of -lipoic acid could prevent blood pressure elevation, insulin resistance, and the increase in aorta superoxide anion production in a new experimental model of hypertension associated with insulin resistance. Sprague-Dawley rats were given 10% D-glucose in their drinking water combined either with a normal chow d...
متن کاملPrevention of chromate induced oxidative stress by alpha-lipoic acid.
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxi...
متن کاملΑ-lipoic Acid Reduces Neurogenic Hypertension by Blunting
22 We previously reported that ACE2 compensatory activity is impaired by the 23 disintegrin and metalloprotease 17 (ADAM17) and lack of ACE2 is associated 24 with oxidative stress in neurogenic hypertension. To investigate the relationship 25 between ADAM17 and oxidative stress, Neuro2A cells were treated with Ang-II 26 (100 nM) 24 h after vehicle or α-lipoic acid (LA: 500 μM). ADAM17 expressio...
متن کاملProtection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
In diabetic patients, alpha-lipoic acid (LA) improves skeletal muscle glucose transport, resulting in increased glucose disposal; however, the molecular mechanism of action of LA is presently unknown. We studied the effects of LA on basal and insulin-stimulated glucose transport in cultured rat L6 muscle cells that overexpress GLUT4. When 2-deoxy-D-glucose uptake was measured in these cells, th...
متن کاملOxidative Stress and Insulin Resistance
OBJECTIVE Although cumulative evidence suggests that increased oxidative stress may lead to insulin resistance in vivo or in vitro, community-based studies are scarce. This study examined the longitudinal relationships of oxidative stress biomarkers with the development of insulin resistance and whether these relationships were independent of obesity in nondiabetic young adults. RESEARCH DESI...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2002
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hy0202.104345