Preventing rheumatic fever: M-protein based vaccine
نویسندگان
چکیده
منابع مشابه
Preventing recurrent rheumatic fever: the role of register based programmes.
Despite dramatic gains of the last century, acute rheumatic fever and rheumatic heart disease remain major preventable causes of morbidity and mortality in many parts of the world.
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Rheumatic fever (RF) is an autoimmune disease which affects more than 20 million children in developing countries. It is triggered by Streptococcus pyogenes throat infection in untreated susceptible individuals. Carditis, the most serious manifestation of the disease, leads to severe and permanent valvular lesions, causing chronic rheumatic heart disease (RHD). We have been studying the mechani...
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Sur 2601 admissions, chez 113 enfants atteints de la maladie de Bouillaud, hospitalises en cinq ans dans deux services de pediatrie de Teheran (C.H.U. de Pahlavi, C.H.U. de Logmandoleh Adham) 6 cas de manifestations cutanees (trois cas de nodules, trois cas d'erytheme marginatum) ont ete constates, trois d'entre eux souffrant d'une cardite severe et evolutive. En Iran !'incidence des si...
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The antigenic relatedness of surface-exposed portions of M protein molecules derived from group A streptococcal isolates representing more than 50 distinct serotypes was examined. The data indicate that the majority of serotypes fall into two major classes. Class I M protein molecules share a surface-exposed, antigenic domain comprising the C repeat region defined for M6 protein. The C repeat r...
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ژورنال
عنوان ژورنال: Indian Heart Journal
سال: 2014
ISSN: 0019-4832
DOI: 10.1016/j.ihj.2013.12.017