Prevalence of Extended-spectrum Beta-lactamase Mediated Urinary Tract Infections in a Tertiary Hospital in Enugu, South East, Nigeria

Extended-Spectrum Beta-Lactamase (ESBL) are a class of plasmid-mediated diverse, complex and rapidly evolving enzymes which hydrolyzes penicillins, monobactams broad-spectrum cephalosporins. There is increasing prevalence ESBL-producing bacteria globally with higher reported in developing countries. The present study was designed to determine the antimicrobial sensitivity pattern ESBL producing isolates patients Urinary Tract Infection (UTI) Enugu. Urine samples were collected from total 284 subjects self-reported UTI In Enugu State University Science Technology Teaching Hospital, State, Nigeria between periods April May,2019.Samples analyzed for presence resistance using standard methods. Data by descriptive statistics SPSS version 23 (IBM Corp Armok, NY). A 145 strains Staphylococcus aureus (n= 19). Escherichia coli (n=52), Klebsiella pneumonia (n=45), Pseudomonas aeruginosa (n =12), Enterococcus faecalis (n=9) Proteus mirabilis (n=8), isolated 132 giving rate 34.6%. Forty-nine (49) comprising (n=5), (n=15), (n=16), (n=13), (n=8) (n=7) implicated accounting 46.8%ESBL-producing mediated UTI. high induced This portends great danger management bacterial infections.