Prevalence and Resistance Profile of Muenchen Cefotaximase (CTX-M) Group 1 Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic <i>Escherichia coli</i> Strains in Dakar, Senegal

Background: Extended-spectrum beta-lactamase (ESBL) producing bacteria are a real public health problem, particularly in Africa. Among these ESBLs, there the Muenchen Cefotaximase (CTX-M) described all over world of which most frequent is CTX-M group 1 CTX-M-15 variant. The objective this study was to determine prevalence ESBL-producing Escherichia coli strains and test their antibiotics susceptibility profile. Methodology: A retrospective cross-sectional descriptive conducted detect ESBL-secreting by synergy test. Identification type ESBL from performed using NG-Test rapid diagnostic (NG-Biotech®). Antibiotic profile determined CA-SFM/EUCAST guidelines 2019. Data entry statistical analysis were with Excel version 2010 SPSS 20.0 respectively. Results: Eighty-two tested. detected 75.6% (n = 62). These highly resistant cefotaxim (100%), aztreonam ceftazidim (85.4%) cefepim (66.1%). They also quinolones, gentamycin sulfadoxine-trimethoprim combination. However, showed sensitivity ertapenem cefoxitin (69.3%), tigecyclin (66%), amikacin combination piperacillin tazobactam active on 30.6% against 6.4% for amoxicillin clavulanic acid. Conclusion: present majority colis trains. Despite production enzyme conferring resistance beta-lactam antibiotics, some remain treat infections caused germs.