Prevalence and Correlates of the Estrogen and Progesterone Receptors (ER/PR), Human Epidermal Growth Factor Receptor-2 (HER-2) and P53 in Breast Cancer: a Cross-Sectional Study

Background & Objective: Breast cancer has a pivotal role in many deaths caused by malignancies. Epidermal growth factor receptor-2 (EGFR-2 or HER-2) and estrogen receptor (ER) have immense predictive values as prognostic factors. cancers that steroid receptors respond to hormone therapy show better prognosis than without receptors.Materials Methods: A retrospective cross-sectional study was performed on 500 pathology blocks of women with breast sent the department Amir-al-Momenin medical educational center, Gerash, Iran, from 2016 2019. Data were analyzed SPSS software (Version-16) via ANOVA test followed Chi-square t-tests. P-value <0.05 considered significant.Results: The utmost type malignancy invasive ductal carcinoma (IDC) at 35.03%. Among ER-positive patients 59.67% HER-2-positive. Nonetheless, among PR-positive 54.74% correlated p53 receptor, distant metastasis HER-2 significantly (P < /i><0.01). However, just /i><0.01).Conclusion: Investigated samples more ER-negative less compared similar studies. Meanwhile, Regarding correlation cancer, especially HER-2-positive patients, there is need perform profound screening programs for histopathological characteristics carcinoma.