Presence of an endonuclease specific for ultraviolet light-irradiated deoxyribonucleic acid in a ultraviolet light-sensitive mouse cell mutant Q31.

Presence of an endonuclease specific for ultraviolet light-irradiated deoxyribonucleic acid in a ultraviolet light-sensitive mouse cell mutant Q31.

Ultraviolet light alteration of cellular deoxyribonucleic acid in vivo.

DNA after irradiation with ultraviolet light was immunogenic in rabbits and elicited serum antibodies reacting specifically with UV-irradiated DNA. The serological reactions were demonstrated by immunodiffusion, complement fixation, and immunofluorescence. By immunofluorescence, antisera reacted with cell nuclei of irradiated tissue sections but not with unirradiated tissue. This method was emp...

Ultraviolet Light Induced Mutation and Deoxyribonucleic Acid Replication in Bacteria.

HE terminal process through which the genetic change induced by ultraviolet Tlight (UV) is incorporated into the genetic apparatus is the initial postirradiation deoxyribonucleic acid (DNA) replication ( HAAS and DOUDNEY 1959; DOUDNEY and HAAS 1960). It has been suggested that two discrete radiation effects are prerequisite to incorporation of the “potential mutation” into DNA ( DOUDNEY, KADA a...

Enhanced experimental metastasis of ultraviolet light-induced fibrosarcomas in ultraviolet light-irradiated syngeneic mice.

Some ultraviolet light (UV)-induced fibrosarcomas produce more experimental pulmonary tumor colonies in UV-irradiated hosts than in normal syngeneic recipients. The number of experimental metastases produced following i.v. injection of these tumors increases in proportion to the dose of UV radiation. This enhancement can be transferred with lymphoid cells to lethally X-irradiated recipients and...

Repair of ultraviolet-irradiated transforming deoxyribonucleic acid in Haemophilus influenzae.

Ultraviolet-sensitive and wild-type Haemophilus influenzae cells were exposed to irradiated and unirradiated transforming deoxyribonucleic acid (DNA) containing a marker which can be linked to another marker in the cells. Lysates were made after various times of incubation and assayed for transforming activity on an excisionless recipient. Repair can be noted as an increase in activity from the...