Prepulse inhibition vs cognitive modulation of the hand-blink reflex

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To blink or not to blink : fine cognitive tuning of the defensive hand blink reflex

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Reflex excitability regulates prepulse inhibition.

Presentation of a weak stimulus, a prepulse, before a reflex-evoking stimulus decreases the amplitude of the reflex response relative to reflex amplitude evoked without a preceding prepulse. For example, presenting a brief tone before a trigeminal blink-eliciting stimulus significantly reduces reflex blink amplitude. A common explanation of such data are that sensory processing of the prepulse ...

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Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex.

The purpose of the present study was to determine the effects of muscarinic cholinergic receptor antagonists and agonists on prepulse inhibition (PPI) of the acoustic startle reflex in rats. The muscarinic receptor antagonist scopolamine (0.03-1.0 mg/kg) produced a significant dose-dependent decrease in PPI without affecting startle amplitude. In contrast, N-methyl scopolamine, the quaternary a...

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Facilitation as well as inhibition of the blink reflex by a visual prepulse requires intact striate cortex.

OBJECTIVE The role of visual cortex in modulation of the human eye blink reflex was assessed. METHODS Participants were 13 patients with unilateral striate cortex damage. Nonreflexogenic gratings were presented in their intact or blind hemifield prior to white noise or air puff blink-eliciting stimuli. RESULTS Inhibition of reflex amplitude was observed at asynchronies ranging from about 12...

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Sensory modulation of the blink reflex in patients with blepharospasm.

OBJECTIVE To measure the effects of a prepulse stimulus on the blink reflex responses elicited by an electrical stimulation of the supraorbital nerve in patients with blepharospasm with and without an effective sensory trick. DESIGN Blink reflexes to supraorbital nerve stimulation were preceded in test trials by a prepulse electrical stimulus to the third finger at various leading intervals. ...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2021

ISSN: 2045-2322

DOI: 10.1038/s41598-021-84241-6