Prepulse inhibition modulation by contextual conditioning of dopaminergic activity
نویسندگان
چکیده
منابع مشابه
Dopaminergic Induced Changes in Mauthner-cell Excitability Disrupts Prepulse Inhibition
Dopaminergic induced changes in Mauthner-cell excitability disrupts prepulse inhibition 1 in the startle circuit of goldfish. 2 3 Violeta Medan and Thomas Preuss 4 5 Department of Psychology, Hunter College, City University of New York 6 695 Park Avenue, New York, NY 10065 7 8 Running head: dopaminergic disruption of prepulse inhibition 9 10 Corresponding author: Thomas Preuss, [email protected]...
متن کاملDifferentially organized top-down modulation of prepulse inhibition of startle.
Prepulse inhibition (PPI) of startle is the suppression of the startle reflex when a weaker sensory stimulus (the prepulse) shortly precedes the startling stimulus. PPI can be attentionally enhanced in both humans and laboratory animals. This study investigated whether the following three forebrain structures, which are critical for initial cortical processing of auditory signals, auditory fear...
متن کاملdopaminergic activity in the medial prefrontal cortex modulates fear conditioning
the purpose of the present study was to determine the role of medial prefrontal cortex (mpfc) dopaminergic system in fear conditioning response considering individual differences. animals were initially counterbalanced and classified based on open field test, and then were given a single infusion of the dopamine agonist, amphetamine (amph) and antagonist, clozapine (clz) into the medial prefron...
متن کاملPharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats.
Prepulse inhibition (PPI) of the acoustic startle reflex is a sensorimotor gating process known to be deficient in a number of neurologic and psychiatric conditions, including schizophrenia. Multiple lines of evidence have indicated that the dopaminergic and muscarinic cholinergic systems play an important role in modulating PPI. Moreover, interactions between the dopaminergic and muscarinic ch...
متن کاملContext pre-exposure obscures amygdala modulation of contextual-fear conditioning.
We report that post-training inactivation of basolateral amygdala region (BLA) with muscimol impaired memory for contextual-fear conditioning (as measured by freezing) and intra-BLA norepinephrine enhanced this memory. However, pre-exposure to the context eliminated both of these effects. These findings provide a likely explanation of why an earler study failed to observe that the BLA modulates...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2013
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2013.06.005