Preparation, characterization and stability of silver sulfadiazine nanoliposomes


 Purpose: To prepare, characterize and investigate the stability drug release profile of silver sulfadiazine (AgSD) nanoliposomes as functions pH, UV exposure, and/or heat.
 Methods: Silver were prepared. The properties free nanoliposomal formulations AgSD heat analyzed. analyses performed at different time points.
 Results: results characterization showed that acidic, basic neutral nano-liposomal suspensions (AgSD NLSs) produced stable homogenous formulations, indicated by low polydispersity index (PDI) high zeta potential. three NLSs unstable under conditions. pH tended to shift towards neutrality, starting from day 1. exhibited similar (100 % was released 12).
 Conclusion: Incorporation into has no significant effect on in vitro drug. This indicates NLS did not change physical characteristics Studies focus only improving lipophilicity may benefit these results.