Preparation and characterization of amphotericin B mannosylated liposomes for effective management of visceral leishmaniasis

Visceral leishmaniasis (VL) is a chronic debilitating disease prevalent in tropical and subtropical regions, caused by protozoan parasites of the genus Leishmania. Annually, it approximated occurrence 0.2 to 0.4 million novel cases worldwide. The cast film method was used prepared cationic mannosylated liposomes. surface Amphotericin B (Amp B)-bearing multilamellar liposomes covalently coupled with p-aminophenyl-?-D-mannoside using glutaraldehyde as coupling agent, which proved agglutination vesicles concanavalin A. were characterized for shape, size, % drug entrapment, vesicle count, zeta potential vitro release. Vesicle sizes establish be 2.71±0.12and 1.62±0.08?m, respectively. Zeta higher (28.38 ± 0.3 mV), compared (15.7 0.8 mV). release from mannose-coupled established 45.7% 41.9%, respectively, after 24 hrs. In present work, Amp prepared, optimized effectual organization VL.
 Keywords: Mannosylated liposomes, B, Leishmaniasis,