Preparation and application of combinatorial library. 1. Combinatorial chemistry and peptide library. (1)
نویسندگان
چکیده
منابع مشابه
A Rapid Combinatorial Library Synthesis of Benzazolo[2,1-b]quinazolinones and Triazolo[2,1-b]quinazolinones
Benzazolo [2,1-b]quinazolinones and triazolo[2,1-b]quinazolinones were synthesized in high yields by the condensation reaction of an aldehyde and a cyclic β-diketone with 2 - aminobenzimidazole, 2 - aminobenzothiazole or 1, 2, 4 - triazole derivatives in 1 - butyl - 3 -methylimidazolium bromide as an ionic liquid under classic heating conditions within 5-60 minutes.
متن کاملIdentification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.
A positional scanning synthetic peptide combinatorial library containing approximately 52 million hexapeptides was used to identify potential inhibitory peptides for recombinant mouse prohormone convertase 1 (PC1) and PC2 and to provide information on the specificity of these enzymes. The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, ...
متن کاملPhotosynthesis of a combinatorial peptide library in the gas phase.
A strategy for generating large numbers of peptides from a relatively small number of precursors based on photosynthetic combination in the gas phase is presented. In this approach, electrospray ionization is used to create a combination of proton-bound dimers from a specified set of peptides present in solution. The dimers are then accumulated and isolated in an ion trap mass spectrometer. Pho...
متن کاملCurrent Status of Virtual Combinatorial Library Design
Combinatorial compound libraries have become an established research tool for finding molecules with desired properties. This review gives an overview on the current status of methods, techniques and design processes for combinatorial libraries. Recent developments include the sequential and parallel use of multiple sophisticated design criteria to select suitable molecules. Diversity measures,...
متن کاملCombinatorial Library of Primaryalkylammonium Dicarboxylate Gelators
Combinatorial Library of Primaryalkylammonium Dicarboxylate Gelators: A Supramolecular Synthon Approach Pathik Sahoo, N. N. Adarsh, George E. Chacko, Srinivasa R. Raghavan, Vedavati G. Puranik, ) and Parthasarathi Dastidar* Department of Organic Chemistry, Indian Association for the Cultivation of Science (IACS), 2A & 2BRaja S C Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India, Depart...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1996
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.34.610