Preoperative risk grade predicts the long-term prognosis of intrahepatic cholangiocarcinoma: a retrospective cohort analysis

Abstract Background Cumulating evidence indicates that the systemic inflammatory response (SIR) plays a crucial role in prognosis of various cancers. We aimed to generate preoperative risk grade (PRG) by integrating SIR markers preoperatively predict long-term intrahepatic cholangiocarcinoma (ICC). Methods 468 consecutive ICC patients who underwent hepatectomy between 2010 and 2017 were enrolled. The PRG nomogram generated their predictive accuracy was evaluated. Results consisted two non-tumor-specific platelet-to-lymphocyte ratio (PLR) albumin (ALB), which both independent predictors overall survival (OS). Multivariate analysis showed significantly associated with OS (PRG = 1: hazard (HR) 3.800, p < 0.001; 2: HR 7.585, 0.001). C-index for predicting 0.685 (95% CI 0.655 0.716), statistically higher than following systems: American Joint Committee on Cancer (AJCC) 8th edition (C-index 0.645), Liver Study Group Japan (LCSGJ) 0.644) Okabayashi 0.633) ( 0.05). Besides, only consisting tumor-specific factors (serum carcinoembryonic antigen, carbohydrate antigen 19-9, tumor number) could be improved 0.737 0.062–0.768) from 0.625 0.585–0.665) when incorporated Conclusions PLR ALB novel method ICC.