Prenatal low-dose methyltestosterone, but not dihydrotestosterone, treatment induces penile formation in female mice and guinea pigs†
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چکیده
منابع مشابه
Prenatal Iron Deficiency in Guinea Pigs Increases Locomotor Activity but Does Not Influence Learning and Memory
The objective of the current study was to determine whether prenatal iron deficiency induced during gestation in guinea pigs affected locomotor activity and learning and memory processes in the progeny. Dams were fed either iron-deficient anemic or iron-sufficient diets throughout gestation and lactation. After weaning, all pups were fed an iron-sufficient diet. On postnatal day 24 and 40, the ...
متن کاملEvaluation of low dose diagnostic X-rays induced effect on the white blood cells count in Guinea pigs
Background: Exposure to ionizing radiation is known to have various effects on hematological parameters of biological sample. This study was aimed at evaluating the effect of ionizing radiation on some hematological parameters in guinea pigs. Materials and Methods: Thirty-six (36) apparently healthy adult guinea pigs of both sexes weighing between 700g – 1200...
متن کاملTestosterone and dihydrotestosterone differentially improve cognition in aged female mice.
Compared with age-matched male mice, female mice experience a more severe age-related cognitive decline (ACD). Since androgens are less abundant in aged female mice compared with aged male mice, androgen supplementation may enhance cognition in aged female mice. To test this, we assessed behavioral performance on a variety of tasks in 22- to 24-mo-old gonadally intact female mice treated for 6 ...
متن کاملCirculating dihydrotestosterone may not reflect peripheral formation.
We compared the blood (PBDHT) and urine (PUDHT) production rate of dihydrotestosterone (DHT) in normal men and women to determine whether peripheral formation was totally reflected in blood. PBDHT was similar when measured at both sites in men (674 +/- 79 vs. 788 +/- 207 SE micrograms/d); however, PUDHT was greater than PBDHT in women (174 +/- 55 vs. 55 +/- 8 micrograms/d, P less than 0.02). Ex...
متن کاملA Dose-Effect Study of Cisplatin Ototoxicity in Albino Guinea Pigs
Introduction: Cisplatin is one of the most commonly used antineoplastic drugs; nonetheless, its ototoxic dose-limiting side effects have remained a significant challenge in clinical practice. The recognition of the exact template of hearing loss induced by multiple low doses of cisplatin could be of great help in managing the treatment process. The present study aimed to investigate the e...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2020
ISSN: 0006-3363,1529-7268
DOI: 10.1093/biolre/ioaa035