Preliminary Report on Hypothalamic Hyperphagia in Ruminants

Food Intake and Hypothalamic Hyperphagia †

Animals eat different amounts of different diets, which implies that they recognize some quality or qualities of the diet. Both Cowgill' and Adolph1 were aware of this problem, but no one appears to have made a systematic attempt to define the dietary quality recognized by animals. Both of these workers were led to the opinion that their animals seemed to "eat for calories," i.e., for energy. H...

Experimental Hypothalamic Hyperphagia in the Albino Rat *

Experimental study of hypothalamic obesity is based upon a foundation laid by clinicians who described lesions of the hypophysiohypothalamic region in obese human patients. Because of the non-specific character of the lesions which they found, previous investigation was naturally directed toward discovering whether damage to the hypothalamus, to the hypophysis, or to both was necessary to produ...

The Effect of Hyperglycemia on Hypothalamic Gold Uptake and Hyperphagia in Goldthioglucose-treated Mice

The accumulation of gold in the hypothalamus and the development of hyperphagia and obesity were studied in mice given a single intravenous injection of goldthioglucose at various levels of blood glucose concentration. It was found that the glucose concentration prevailing at the time of goldthioglucose injection was correlated directly with the level of free and bound goldthioglucose in the bl...

Sex differences in hyperphagia and body weight gains following goldthioglucose-induced hypothalamic lesions in mice*

Hypothalamic damage was induced in age-matched male and female albino mice by goldthioglucose injection, and their food consumption and body weight were compared over the following 60-day period. Sex differences in food consumption were also investigated as a function of palatability of food. Results show no significant sex differences in food consumption, although marked sex differences in bod...

Preliminary Report on GenericNegotiatorDajun