Pregnancy and Antiphospholipid Syndrome

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منابع مشابه

Antiphospholipid Syndrome in Pregnancy

The antiphospholipid syndrome (APS) is a multisystemic disease, characterized by venous or arterial thromboses, or certain obstetric complications, and the presence of antiphospholipid antibodies (APAs)(1-4). APAs are a heterogeneous group of autoantibodies that bind to negatively charged phospholipids, phospholipid-binding protein, or a combination of the two. Lupus anticoagulant (LA), anticar...

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Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts

Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent e...

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Diagnosis and management of antiphospholipid syndrome in pregnancy

Key content: • The diagnosis of antiphospholipid syndrome (APS) requires both characteristic clinical features and persistently abnormal laboratory tests. • Antiphospholipid syndrome can cause serious morbidity in mother and fetus. • Good management in an expert setting can result in a live birth rate of 80%. • Prepregnancy assessment and counselling play an important part in optimising the cha...

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Obesity and Antiphospholipid Syndrome: A Particular Challenge in Pregnancy

Obesity is associated with a broad spectrum of chronic diseases, as well as cardiovascular diseases, such as diabetes, dyslipidemia, insulin resistance and hyperglycemia. Obesity during pregnancy is of major concern due to the well-known risk factors for both the mother and the child. Complications in pregnancy include recurrent miscarriages, gestational diabetes, hypertensive disorders, thromb...

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Antiphospholipid (Hughes) syndrome: beyond pregnancy morbidity and thrombosis

The antiphospholipid syndrome is an autoimmune disease characterised by recurrent arterial or venous thrombosis, pregnancy morbidity and the persistence of positive antiphospholipid antibodies. Many other clinical manifestations may occur including heart valve disease, livedo reticularis, thrombocytopenia and neurological manifestations such as migraine and seizures. We review a number of other...

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ژورنال

عنوان ژورنال: American Journal of Reproductive Immunology

سال: 2012

ISSN: 1046-7408

DOI: 10.1111/aji.12071