Preferences for cocaine- or pup-associated chambers differentiates otherwise behaviorally identical postpartum maternal rats
نویسندگان
چکیده
منابع مشابه
Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats.
Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams a...
متن کاملPreference for cocaine- versus pup-associated cues differentially activates neurons expressing either Fos or cocaine- and amphetamine-regulated transcript in lactating, maternal rodents.
We studied the neuronal basis of the motivational response to two powerful but radically different rewards-cocaine and maternal nurturing of pups in the postpartum rat (dam) which is in a unique motivational state. We used a place preference method designed to offer a choice between cues associated with a natural reinforcer (pups) and those associated with a pharmacologic reinforcer (cocaine). ...
متن کاملDistal pup cues evoke dopamine responses in hormonally primed rats in the absence of pup experience or ongoing maternal behavior.
During the early postpartum period or following estrogen/progesterone administration, pups elicit maternal behavior accompanied by a robust dopamine (DA) response in the nucleus accumbens (NAC) of female rats (Afonso et al., 2009). To determine whether DA responds to ostensibly "salient" stimuli in the absence of consummatory behaviors, we examined NAC shell DA responses during restricted (stim...
متن کاملBehavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus maze.
The present study investigated the validity of a novel pup-based repeated elevated plus maze task to detect reduced anxiety and increased maternal responsiveness in postpartum female rats and explored the roles of dopamine D2, serotonin transporter and GABA/benzodiazepine receptors in the mediation of these processes. Sprague-Dawley postpartum or nulliparous female rats were tested 4 times ever...
متن کاملBoth High and Low Doses of Cocaine Derail Normal Maternal Caregiving – Lessons from the Laboratory Rat
and maternal aggression (Zimmerberg and Gray, 1992; Johns et al., 1994, 1998; Kinsley et al., 1994). These studies use dosages and treatment regimes of cocaine that model, to some extent, drug use patterns and dosages reported in the dependent human user. Commonly used dosages in these studies result in peak plasma levels of approximately 200–900 ng/ml of cocaine (10–40 mg/kg injected), closely...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2003
ISSN: 0033-3158
DOI: 10.1007/s00213-002-1351-4