Predictors of treatment response in cirrhotic patients with overt hepatic encephalopathy

Introduction: Hepatic encephalopathy (HE) is a frequent complication and one of the most debilitating manifestations liver cirrhosis, which negatively impacts patient survival. This study aims to identify factors influencing treatment response in patients with cirrhosis HE.
 Method: was prospective observational conducted from July 2019 June 2020 tertiary referral center Nepal. The ethical clearance obtained Institutional Review Board (Reference No. 46/076/77). Patients Liver HE grade II or more were included. Standard medical therapy for given all patients, first five days post admission recorded. categorized as good response, no deterioration, based on improvement deterioration patient`s symptoms changes West Haven criteria.
 Result: In this total 78 enrolled included final analysis. mean age 50.17± 10.36 years 63(80.76%) male. Alcohol etiology 62(79.5%). Seventy two (92.3%) had treatment, 3(3.8 %) rest 3(3.8%) deteriorated. On logistic regression, high creatinine, bilirubin low serum protein predictors non-response standard (p<0.05).
 Conclusion: High Cirrhosis Encephalopathy.