Predictors of dimercaptosuccinic acid chelatable lead and tibial lead in former organolead manufacturing workers
نویسندگان
چکیده
منابع مشابه
Predictors of dimercaptosuccinic acid chelatable lead and tibial lead in former organolead manufacturing workers.
OBJECTIVES To identify predictors of tibial and dimercaptosuccinic acid (DMSA) chelatable lead in 543 organolead manufacturing workers with past exposure to organic and inorganic lead. METHODS In this cross sectional study, tibial lead (by 109Cd K-shell x ray fluorescence), DMSA chelatable lead (4 hour urinary lead excretion after oral administration of 10 mg/kg), and several exposure measure...
متن کاملAssociations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers.
We evaluated associations of tibial lead levels with polymorphisms in the vitamin D receptor (VDR) in 504 former organolead manufacturing workers with past exposure to lead. In this cross-sectional study, we measured tibial lead by (109)Cd K-shell X-ray fluorescence. Tibial lead was evaluated in subjects with different VDR genotypes defined using the BsmI restriction enzyme, adjusting for confo...
متن کاملComparison of measures of lead exposure, dose, and chelatable lead burden after provocative chelation in organolead workers.
OBJECTIVES To describe 6 h urinary lead excretion (6 h PbU) after 1 g intravenous ethylene diamine tetraacetic acid (EDTA) in organolead manufacturing workers with mixed exposure to organic and inorganic lead; to determine the predictors of lead excretion (PbU); and to determine the extent to which internal lead stores and ongoing external exposure govern blood concentrations of lead (PbB). M...
متن کاملEvaluation of cumulative lead dose and longitudinal changes in structural MRI in former organolead workers
Objective—We evaluated whether tibia lead was associated with longitudinal change in brain volumes and white matter lesions in male former lead workers and population-based controls in whom we have previously reported on the cognitive and structural consequences of cumulative lead dose. Methods—We used linear regression to identify predictors of change in brain volumes and white matter lesion g...
متن کاملAssociations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes.
A cross-sectional study was performed to evaluate the influence of polymorphisms in the [delta]-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes on blood lead, tibia lead, and dimercaptosuccinic acid (DMSA)-chelatable lead levels in 798 lead workers and 135 controls without occupational lead exposure in the Republic of Korea. Tibia lead was assessed with a 30-min measur...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1999
ISSN: 1351-0711
DOI: 10.1136/oem.56.1.22