Predictive value of the aspartate aminotransferase to platelet ratio index and aspartate aminotransferase to alanine aminotransferase ratio in early diagnosis of intrahepatic cholestasis in pregnancy

Objective: We aimed to investigate the predictive value of first-trimester aspartate aminotransferase/platelet count ratio index (APRI) and aminotransferase/alanine aminotransferase for intrahepatic cholestasis in pregnancy (ICP).
 Material Methods: The clinical data patients who admitted Obstetrics Department Umraniye Training Research Hospital, between 2015-2020 were analyzed retrospectively. study group consisted 44 with ICP control randomly selected 92 healthy pregnant women.
 Results: two groups similar terms age, BMI, first third-trimester platelet hemoglobin level. Patients had a significantly higher APRI lower trimester AST/ALT than controls (p <0.001, p = 0.001, respectively). According ROC analysis, optimal cut-off predict was 0.191, sensitivity 0.66 specificity (AUC: 0,727), 1.07, 0.64, 0.62 0,681).
 Conclusion: score is an easy, inexpensive, non-invasive tool that may be useful predicting early.