Predictive validity of behavioural animal models for chronic pain
نویسندگان
چکیده
منابع مشابه
Predictive validity of animal pain models? A comparison of the pharmacokinetic-pharmacodynamic relationship for pain drugs in rats and humans.
A number of previous reviews have very eloquently summarized pain models and endpoints in animals. Many of these reviews also discuss how animal models have enhanced our understanding of pain mechanisms and make forward-looking statements as to our proximity to the development of effective mechanism-based treatments. While a number of reports cite failures of animal pain models to predict effic...
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The objectives of this study were to (1) determine the frequency of the MMPI profile types identified by Marks and Seeman (1963) among chronic pain patients, and (2) determine the predictive validity of the profile types found. One thousand, six hundred and seven valid MMPIs from chronic pain patients seen at a multidisciplinary pain center for possible inpatient treatment were categorized into...
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BACKGROUND The treatment of chronic low back pain is not primarily focused on removing an underlying organic pathology, but at the reduction of disability through the modification of environmental contingencies and cognitive processes. Behavioural interventions are commonly used in the treatment of chronic (disabling) low back pain. OBJECTIVES The objective of this systematic review was to de...
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To facilitate the study of pain transmission and the characterization of novel analgesic compounds, an array of experimental animal pain models has been developed mainly in rodents. In these preclinical models, nociceptive pain can be measured by both spontaneous and evoked behaviors. Acute pain (seconds to hours) can be more easily measured, albeit still with some difficulty, by spontaneous be...
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Chronic pain is a major health care problem throughout the world. Available data indicate that acute pain syndromes cont~bute significantly to health care costs but that chronic or recurrent pain produces an even greater economic burden in addition to social and psychological problems [8,19]. As the medical and scientific community has become aware that chronic pain is different from acute pain...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2011
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2011.01300.x