Predictive models in clinical practice: useful tools to be used with caution

Lexical Features in Coreference Resolution: To be Used With Caution

Lexical features are a major source of information in state-of-the-art coreference resolvers. Lexical features implicitly model some of the linguistic phenomena at a fine granularity level. They are especially useful for representing the context of mentions. In this paper we investigate a drawback of using many lexical features in state-of-the-art coreference resolvers. We show that if corefere...

Liposome-mediated RNA transfection should be used with caution.

Liposome-mediated RNA transfection appears to present a number of advantages for studying the metabolism of reporter mRNAs in mammalian cells. This method is also widely used to transfect siRNAs. Here we describe results indicating that reporter mRNAs introduced into HeLa cells by liposomes do not present the expected behaviors. Namely, the stability of reporter mRNAs was independent of the pre...

Transfection of microRNA Mimics Should Be Used with Caution

Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used extensively to study the functions and mechanisms of endogenous miRNAs. However, it remains unclear whether transfected miRNAs behave similarly to endogenous miRNAs. Here we show that transient transfection of miRNA mimics into HeLa cells by a commonly used method led to the accumulation of high molecular wei...

Effective ambulatory blood pressure control in medical practice: good news to be taken with caution.

A large number of studies has addressed the question of how effective is blood pressure (BP) control in the hypertensive population,1–3 with a consistent and unequivocal answer. That is, BP control is disappointingly low, because only a small fraction of patients diagnosed as having a BP elevation show on-treatment BPs 140 mm Hg systolic and 90 mm Hg diastolic, which are the target values for t...

receiver operating characteristic curve and odds ratio should be used with caution