Predictive Markers Require Thorough Analytic Validation
نویسندگان
چکیده
منابع مشابه
Challenges in Development and Validation of Surrogate and Predictive Markers
Molecular heterogeneity exists even within tumors derived from the same tissue of origin, and clinical benefit associated with any drug is typically limited to a subset of patients. This aspect of cancer and cancer therapy remains the most challenging, even in the current era of “targeted therapy,” which is characterized by a move from the empiric approach of “one size fits all” to personalized...
متن کاملImmune monitoring technology primer: clinical validation for predictive markers
Background: Recent biotechnological developments have resulted in increasing interest in immunology biomarkers. These biomarkers have potential clinical utility in the near future as predictors of treatment response. Hence, clinical validation of these predictive markers is critical. Findings: The process of clinically validating a predictive biomarker is reviewed. Validation of a predictive bi...
متن کاملHow Thorough Is Thorough Enough?
Abstraction is the key for effectively dealing with the state explosion problem in model-checking. Unfortunately, finding abstractions which are small and yet enable us to get conclusive answers about properties of interest is notoriously hard. Counterexample-guided abstraction refinement frameworks have been proposed to help build good abstractions iteratively. Although effective in many cases...
متن کاملPredictive Immunological Markers in Oncology
Most treatment decisions in oncology are still based on histomorphological criteria, criteria that are incorporated in actual staging systems. With just a few exceptions (i.e., leukemias, some lymphomas, GIST, NSCLC, etc.) molecular and immunological characteristics of individual tumors do not contribute to this process. The basis for clinical considerations and treatment indications are clinic...
متن کاملPredictive markers of radiation pneumonitis.
Radiation pneumonitis is an acute-phase response to radiation therapy and a common complication that affects a patient's quality of life. Under the need to reduce the incidence and severity of radiation-induced pulmonary complications as well as to identify patients at risk, several investigations on potential predictive markers of radiation pneumonitis have been conducted. The present study re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Pathology & Laboratory Medicine
سال: 2019
ISSN: 0003-9985,1543-2165
DOI: 10.5858/arpa.2019-0112-le