Prediction strength modulates responses in human area CA1 to sequence violations

Prediction strength modulates responses in human area CA1 to sequence violations.

Emerging human, animal, and computational evidence suggest that, within the hippocampus, stored memories are compared with current sensory input to compute novelty, i.e., detecting when inputs deviate from expectations. Hippocampal subfield CA1 is thought to detect mismatches between past and present, and detected novelty is thought to modulate encoding processes, providing a mechanism for gati...

1 Prediction strength modulates responses in human area CA 1 to 2 sequence violations 3 4 5

23 24 Emerging human, animal, and computational evidence suggests that, within the 25 hippocampus, stored memories are compared to current sensory input to compute 26 novelty – i.e., detecting when inputs deviate from expectations. Hippocampal subfield 27 CA1 is thought to detect mismatches between past and present, and detected novelty is 28 thought to modulate encoding processes, providing a ...

The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area

Chemokines have several physio-pathological roles in the brain. Among them, the modulation of synaptic contacts and neurotransmission recently emerged as crucial activities during brain development, in adulthood, upon neuroinflammation and neurodegenerative diseases. CXCL16 is a chemokine normally expressed in the brain, where it exerts neuroprotective activity against glutamate-induced damages...

A hierarchy of cortical responses to sequence violations in three-month-old infants.

The adult human brain quickly adapts to regular temporal sequences, and emits a sequence of novelty responses when these regularities are violated. These novelty responses have been interpreted as error signals that reflect the difference between the incoming signal and predictions generated at multiple cortical levels. Do infants already possess such a hierarchy of violation-detection mechanis...

Editorial: Psychological Responses to Violations of Expectations