Prediction of MHC Class II binders/non-binders using negative selection algorithm in vaccine designing
نویسندگان
چکیده
منابع مشابه
Identification of MHC Class II binders/ non-binders using Negative Selection Algorithm
The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine designing. These MHC class – II peptides are predominantly recognized by CD4+ T-helper cells, which when turned on, have profound immune regulatory effects. Thus, prediction of such MHC class-II binding peptide is very he...
متن کاملPrediction of MHC class II binders using the ant colony search strategy
OBJECTIVE Predictions of the binding ability of antigen peptides to major histocompatibility complex (MHC) class II molecules are important in vaccine development. The variable length of each binding peptide complicates this prediction. METHODOLOGY Motivated by the search properties of the ant colony system (ACS), a method for the identification of an alignment for a given set of short protei...
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MOTIVATION Prediction methods for identifying binding peptides could minimize the number of peptides required to be synthesized and assayed, and thereby facilitate the identification of potential T-cell epitopes. We developed a bioinformatic method for the prediction of peptide binding to MHC class II molecules. RESULTS Experimental binding data and expert knowledge of anchor positions and bi...
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Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, allowing binding of peptides extending out of the binding groove. Furthermore, only a few HLA-DR all...
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MOTIVATION Prediction of which peptides will bind a specific major histocompatibility complex (MHC) constitutes an important step in identifying potential T-cell epitopes suitable as vaccine candidates. MHC class II binding peptides have a broad length distribution complicating such predictions. Thus, identifying the correct alignment is a crucial part of identifying the core of an MHC class II...
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ژورنال
عنوان ژورنال: Journal of Bioinformatics and Sequence Analysis
سال: 2013
ISSN: 2141-2464
DOI: 10.5897/jbsa11.023